Clopidogrel and Omeprazole Drug-Drug Interaction

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Tue, 03/03/2026 - 15:44

Jocelyn George

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Joined: 01/19/2023 - 11:10

Clopidogrel and Omeprazole Drug-Drug Interaction

Good Afternoon,

Our organization received a request to re-evaluate drug-drug interaction severity level of the DDI between Clopidogrel and Omeprazole. Currently, the DDI level is a soft alert for providers, however, there is a request to increase the severity to a hard stop which would require override alert. In our organization, assigning the DDI level to a drug pair requires primary literature review. When there is a request to either raise the severity of the DDI drug pair or entering a new DDI from an end user, we require submitting the request with primary literature. However, we recognize this may not be possible for a clinician and the request is submitted using tertriary sources such as LexiComp or Micromedex. Lexicomp classifies this DDI as "Avoid Combination".

How does your hospital system handle this DDI?

Any insight is appreciated.

Thanks,
Jocelyn

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