MSOS Discussion Board

USP BUD vs Expiration Date

Gregory Mak's picture

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Hello!

We have received reports of confusion from our nursing staff regarding BUD vs expiration date.

Our hospital gives a standard 24h BUD for most compounds from pharmacy as that generally falls within the USP limits. Nurses are interpreting this as an expiration date and are not comfortable infusing medications that would run past that BUD.

This also leads to confusion regarding medications where the stability dictates an expiration time that is shorter than our standard BUD. Nursing would like a one-size fits all solution but I don't know if one exists.

Intratheccal dexmedetomidine

Carol Labadie's picture

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Are you seeing adverse effects from intrathecal dexmedetomidine?
Anesthesia started using dexmedetomidine intrathecally for OB patients and noticing side effects; specifically an increase in time of epidural duration and decrease in fetus heart rate, Is the intrathecal route being used for other indications? Have other side effects been noticed/identified?

Hospira Heparin without intended ACT effect

Julie A DAmbrosi's picture

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We have received reports from our cath/EP lab of patients not demonstrating the intended anticoagulant effect, a therapeutic ACT, from Hospira's Heparin 10,000 units/10 ml NDC 0409-2720-31, lot HA0269, exp 2/1/2025 following administration of typical bolus doses of this product. Alternative heparin product did result in intended effect. Case reviews are underway for identifiable contributing factors to heparin resistance.

This experience has been reported to FDA and manufacturer.

Anyone else identifying similar experience?

Liquid Pre-packers

Alexander Milligan's picture

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Interested to hear if any institutions succesfully utilize any of the liquid pre-packers available on the market, such as Fluidose or the Speedy Wet Cadet. If anyone uses these, I would love to hear about your experience (wins/pitfalls/etc.) so I can either start trying to build a case, or look for alternative options. Thanks for your consideration!

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