Fosaprepitant (Emend) Reactions

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Mon, 06/09/2025 - 11:43
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Perry Shafner
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Joined: 02/08/2022 - 11:18
Fosaprepitant (Emend) Reactions

We have seen an uptick in reactions to Emend, with two in April (1.5% of cases) and four in June (7.7% of cases). Reactions included chest tightness, facial flushing, and itching.

Has anyone else noticed an increased incidence of Emend reactions?

NDC: 72205-083-01
Lot: CSE09034A
Exp: 8/31/27

NDC: 72205-083-01
Lot: CSE10035A
Exp: 9/30/27

We mix fosaprepitant 150 mg in 100 ml of NS and store it refrigerated for 10 days. (Based on: Martínez-Gómez MA, Gil AM, Oltra BP, Martí MC (2014) Physico-Chemical Stability of Mixtures of Fosaprepitant used in Clinical Practice. J Anal
Bioanal Tech 5: 197 doi:10.4172/2155-9872.1000197)

The infusion is given over 20 minutes.

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