Our Pediatric Hematology Oncology Physician has noticed a toxicity pattern with our leukemia patients receiving high dose methotrexate. It seems that the patients have had delayed clearance and more severe myelosuppression than usual. She feels that it could be related to the product we purchase. We currently purchase methotrexate manufactured from Accord/Hospira and Teva. The manufacturers haven't had any recalls to date. I was wondering if anyone in our MSOS group, who purchases methotrexate from these manufacturers, have noticed the same patterns.
Thank you for your help.