Fosaprepitant (Emend) Reactions

PLEASE NOTE:   Posts made to this forum should not be considered as the expressed opinions of, nor should be considered endorsed by, the Medication Safety Officer’s Society (MSOS) or the Institute for Safe Medication Practices (ISMP). 

Make sure your email is up-to-date
In order to continue to receive updates from MSOS, as well as forum posts and other valuable information as a member of MSOS, please be sure to update your email address with us, whenever it changes. If you need assistance doing so, please send an email to cmichalek@ismp.org. 

3 posts / 0 new
Log in or register to post comments
Last post
Mon, 06/09/2025 - 11:43
#1
Perry Shafner
Perry Shafner's picture
Offline
Last seen: 1 hour 30 min ago
Joined: 02/08/2022 - 11:18
Fosaprepitant (Emend) Reactions

We have seen an uptick in reactions to Emend, with two in April (1.5% of cases) and four in June (7.7% of cases). Reactions included chest tightness, facial flushing, and itching.

Has anyone else noticed an increased incidence of Emend reactions?

NDC: 72205-083-01
Lot: CSE09034A
Exp: 8/31/27

NDC: 72205-083-01
Lot: CSE10035A
Exp: 9/30/27

We mix fosaprepitant 150 mg in 100 ml of NS and store it refrigerated for 10 days. (Based on: Martínez-Gómez MA, Gil AM, Oltra BP, Martí MC (2014) Physico-Chemical Stability of Mixtures of Fosaprepitant used in Clinical Practice. J Anal
Bioanal Tech 5: 197 doi:10.4172/2155-9872.1000197)

The infusion is given over 20 minutes.

Tags: 

Top